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Viagra Safe for Men With Heart Disease

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Feb. 12, 2002 — If you’re strong enough to take the sex, you’re strong enough to take Viagra. A new study finds Viagra safe for men with heart disease — if they’re able to exercise without having the symptoms of severe disease.

Men taking nitrate drugs (such as generic online order viagra
) to ease the symptoms of heart disease can’t use Viagra. Even when a man isn’t taking nitrates, there’s been concern that Viagra might make his underlying heart disease much worse. There have been reports of men suffering heart attacks or chest pain after taking the popular erectile dysfunction drug.

Adelaide M. Generic pack viagra
, MD, PhD, led a team of Mayo Clinic effects of viagra on woman
s who studied the effects of Viagra on 105 men with coronary artery disease (or heart disease). The men took Viagra or a harmless sugar pill an hour before exercise tests. Then medications were switched, and the men exercised and were tested again.

The results: Viagra itself didn’t make exercise harder on the heart.

“It seems more likely that the heart attacks and pain reported with Viagra are related more to the performance of sexual activity in a patient with coronary artery disease than the use of the drug,” notes Thomas H. Marwick, MD, PhD. Marwick is a heart disease researcher at the University of Queensland in Brisbane, Australia. The Arruda-Olson study, and Marwick’s accompanying editorial, appear in the Feb. 13 issue of TheJournal of the American Medical Association.

Arruda-Olson and co-workers warn that men with heart disease should see their doctors before taking Viagra. They viagra vs levitra
exercise tests to determine whether patients’ hearts are strong enough for the drug.

The researchers warn that men taking impotence vitamins
drugs for their heart condition should not take Viagra.

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Viagra, Paxil Help Premature Ejaculation

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May 29, 2002 — Once again, Viagra comes to the rescue.

A new study shows that Viagra in dysfunction pill
with Paxil helps premature ejaculators who have not improved with standard treatment.

If a man can work up the nerve to talk to his doctor about premature erectile dysfunction pill
, the doctor may refer him to a psychiatrist or a sex therapist, or may prescribe one of several possible sildenafil citrate india including Paxil, an antidepressant, or a lidocaine numbing ointment that is rubbed on the head of the penis before sex.

The study, presented this week at the annual meeting of the American Urological Association in Orlando, Fla., looked at 138 premature ejaculators who started out using a numbing ointment. Thirty-eight were satisfied with that treatment. The remaining 100 started taking Paxil, and 42 of them were satisfied with that, leaving 58 who took Paxil with Viagra.

Over the course of three months, the men took one dose of Paxil seven hours before sex and one dose of Viagra one hour before sex. They noted how long they were able to have sexual intercourse, from the moment they entered a partner’s vagina to the moment they ejaculated. In the beginning, they were able to sustain intercourse for less than one minute to three minutes.

They also rated their performance on a scale. At first they ejaculated too soon from “half of the time” to “almost always.”

By the end of the study, 56 of the 58 men were able to have intercourse for more than three minutes most of the time.

It’s well known that Paxil has sexual side effects, including delayed ejaculation. But Viagra? There can be several explanations for this, says study author Juza Chen, MD, of the Tel Aviv Sourasky Medical Center in Israel.

One possibility is that Viagra acts on the part of the brain that controls ejaculation. This function involves the chemical nitric oxide. Too much nitric oxide inhibits ejaculation. Viagra increases the amount of nitric oxide in the body, which is how it helps men get erections. Juza says there is some scientific evidence that Viagra increases the amount of nitric oxide in the brain, although that is not certain.

“Another possibility could be a decrease of sensitivity in the head of the penis,” Juza says.

Arnold Melman, MD, head of the urology department at the Montefiore Medical Center in New York City, says he doubts that has anything to do with it. “What evidence is there?” he says. “Do you think when you have a hard erection you’re less sensitive?”

Viagra may have had a psychological effect, too: With a firmer erection, they had more confidence, so they had more control. Melman says he thinks that is a more likely explanation. “I’m sure that’s true,” he says. “Much of the reason for premature ejaculation is psychological, not physical.”

Juza says more research is needed to learn about using Viagra as a treatment for premature ejaculation. He plans to study the effects of Viagra alone compared with a placebo, and Viagra alone compared with Paxil alone.

“I think it’s a good concept,” Melman says.

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Italian Study: Viagra May Be Risky for Men With Heart Failure

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Sept. 25, 2001 — We’ve all heard and laughed at Viagra jokes. Poking fun at “the little blue pill” is a favorite of late-night talk show hosts and regular folks alike. But for men with erectile cialis soft tablet
and their partners, the hope Viagra offers — of restoring a healthy sex life — is no laughing matter.

There have, however, been worrisome reports of health risks linked to the drug. Now Italian researchers say that taking Viagra can be deadly if users also have chronic heart failure, a condition where the heart is unable to pump healthy amounts of blood through the body.

Their new study, led by Gianfranco Picirillo, MD, of Medical Policlinic Umberto I in Rome, looked at the heart rhythms of 10 healthy men and 10 others with chronic heart failure after they took a standard dose of Viagra. While both groups experienced certain changes to their heart’s normal electrical activity, those changes were more pronounced and were potentially more dangerous in the men with heart failure.

The scientists conclude that for men with heart failure, taking Viagra may result in abnormal heart rhythms, or arrhythmias, that could lead to sudden death. The risk is even more pronounced, they theorize, for patients who also take certain other drugs including certain antibiotics, antihistamines, antifungals, and erectile dysfunction medication
medications.

But other heart experts are not convinced there’s anything to worry about.

“What we know about Viagra is clear,” says Gary S. Francis, MD, director of the coronary intensive care unit at The Cleveland Clinic Foundation. “Physicians are well aware of it. The drug should not be taken with nitrates nitroglycerin because there’s a risk of sudden, dangerously low blood pressure,” he says. There has been no evidence, however, that heart failure patients in general should avoid Viagra, he tells WebMD.

Rony Shimony, MD, FACC, says that people with heart failure who have a weak heart and irregular heartbeats automatically have a higher death rate than healthy people.

“You’re already in a higher risk group,” says the attending purchase sildenafil citrate at Lenox Hill Hospital and at Cornell Columbia Female herbal viagra
Medical Center, in New York City. He says that these sudden deaths can’t necessarily be linked to Viagra and that the study “is not a reason to panic. Heart failure patients are at higher risk to start with,” he tells WebMD.

What’s more, says Shimony, “cardiac patients are clearly at increased risk from doing any form of exercise or taking any form of medication. You have to use common sense.” No doctor would prescribe Viagra to a very ill patient, he tells WebMD, but if you’re appropriately screened by your heart doctor, even if you have well-controlled heart failure, all evidence indicates that you will not drop dead.

According to Shimony, “the overall experience of the medical community has been that Viagra is a very safe drug” without long-term side effects. But because it is used only to enhance the quality of life, rather than prolong it, “when a doctor prescribes Viagra and something bad happens, that’s when the drug comes under great scrutiny.”

Francis does not completely dismiss the notion that something may be going on here, but erectile pill
more work is needed to determine if the findings are important or not. Results from any test conducted on only 10 people “don’t mean a whole lot,” he says, but this one small study suggests is “that the use of Viagra in patients with heart failure has the potential to alter the electrical stability of the heart.” And that change, he says, “may predispose them to arrhythmias, some of which may be fatal.”

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With Regular Exercise, You May Never Need Viagra

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Aug. 30, 2000 –The popular drug Viagra has improved the lives
of millions, but regular exercise could make it obsolete, according to a report
in the journal Urology.

In the first study of its kind, pills
showed that
physically active men have a lower risk of developing erectile erectile dysfunction meds
(ED)
than inactive men, even if they don’t begin exercising until midlife. But
surprisingly, the study found that reducing tobacco and alcohol use and losing
weight in midlife didn’t reduce a man’s risk of developing erectile
dysfunction.

“Our study showed that men who burn 200 calories a day,
often by walking briskly for about two miles, can lower their risk of ED
significantly,” says study co-author Irwin Goldstein, MD, a professor of
urology at Boston University School of Medicine. “And men who burn more
than 200 calories a day can lower their risk even more.”

Defined as the inability to have or maintain an erection,
erectile dysfunction affects over half of all men between 40 and 70 years of
age, but isn’t dysfunction pills
part of aging.

For their study exploring the effects of lifestyle changes on
ED, Goldstein and colleagues interviewed nearly 600 healthy men ranging from
40-70 years of age. After their body mass was calculated, the participants were
polled about their physical activity, smoking habits, alcohol use, and sexual
function. Eight years later, the process was repeated.

Unlike regular exercise, smoking cessation, alcohol reduction,
and weight loss in midlife didn’t reduce the risk of developing erectile
dysfunction, according to the study. “This suggests that midlife changes
are too late to reverse their effects,” Goldstein cautions, “and
highlights the importance of adopting healthy behaviors early in life.”

One of the major causes of erectile dysfunction is hardening of
the arteries, which reduces the amount of blood that can enter and enlarge the
penis. “That’s why we say that good heart health is needed for good
sexual health,” says William Steers, MD, professor and chairman of urology
at University of Virginia in Charlottesville.

“In fact, ED may be an early warning sign of a future heart
attack or stroke,” Steers tells WebMD. “So think about some other ways
to reduce your risk of heart disease and diabetes,” he urges. For example,
men should:

  • Stop smoking cigarettes and cigars
  • Get their blood pressure under control
  • Reduce dietary fat to lower their cholesterol
  • Lose excess weight for their height
  • Limit alcohol to one or two drinks a day

But even men who get started on a healthy lifestyle early in
life may experience impotence occasionally. “Drug dysfunction erectile
factors like
depression and anxiety can put the brakes on sexual function, but stress is
probably a bigger issue,” says Drogo Montague, MD, director of the Center
for Sexual Function at Ohio’s Cleveland Clinic and chairman of the American
Urological Association’s ED Guidelines Panel. “It can even lead to
persistent difficulty, so look for ways to relax and clear your mind.”

He also advises that men looking to avoid ED:

  • Get adequate sleep to reduce fatigue
  • Plan some time together with their partner, away from the kids
  • Avoid alcohol before sex

Also, “a common cause of permanent impotence is physical
trauma like spinal cord injuries and pelvic fractures, so remember to wear your
seat belt,” Montague says.

The study was supported by the National Institutes of
Health.

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Viagra Doesn’t Damage Vision

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Jan. 8, 2003 — For men taking Viagra, an unnerving side effect — light generic pill viagra
, bluish-colored vision — has been a concern. But there’s no evidence that Viagra causes eye damage, even in those who take high doses, according to a new study.

Since Viagra lowers blood pressure overall, there was a pills
that the drug might decrease blood flow to optic nerves — nerves that control vision — which can cause nerve damage.

However, this study of 13 men at Stanford University found that high doses of Viagra by and large preserved the thickness of the choroid layer of the eye, indicating that blood flow was normal. There were some small variations in thickness, which indicated that some men with an underlying blood vessel condition — such as hardening of the arteries — may indeed have changes in vision.

The study appears in the November-December 2002 issue of Ophthalmologica.

Some of the men did have more clinical pharmacology tadalafil
discriminating between shades of blue and green. However, those men had trouble seeing the difference between many colors.

“Viagra can change blood vessel structure as well as general blood pressure, so we needed to answer the question whether the drug could change blood vessels in the eye,” says lead researcher Tim McCulley, MD, assistant professor of erectile dysfunction medication
at Stanford University, in a news release.

“Our study may have had a small group of dysfunction pills
, but it showed very little change in blood vessels or blood flow in nearly all the patients,” he says.

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Herbal Viagra Alternative Works — at Least on Rats

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Oct. 23, 2000 — It’s not yet clear whether what works for rats might be effective for humans. But one study is showing that an ‘herbal Viagra’ mixture really can help if things get dicey in the rat boudoir.

The study, featured in this month’s Journal of Urology, showed that the herb mixture, based on an ancient Chinese formula, achieved “significant results” in terms of erections for laboratory rats, reports study author Tom F. Lue, MD, a urology researcher at the University of California, San Francisco.

For Lue’s study, the researchers put 24 young rats on a high-100 90 generic viagra
diet that induced erectile dysfunction. “Health issue sexual
is bad for men and rats alike,” he tells WebMD.

Two months into the four-month study, a commercially available herbal mix called BetterMAN was slipped into the drinking water of 16 of the rats.

All the rats fed the high-cholesterol diet indeed ended up with high cholesterol levels — and all became impotent. But those who drank the herbal mixture were later able to achieve erections, while the other eight rats remained impotent.

In the normal course of their short lives, Lue tells WebMD, rats often do experience erectile dysfunction — usually by the time they are 24 months old (about 70 in human years).

The results of his study are strictly ed tabs
, says Lue. “This pilot study is designed to see whether the treatment does anything at all,” he says. “One always has to be cautious when trying to extrapolate findings from rats to humans.”

BetterMAN is an 18-herb mix based on a formula used in traditional Chinese medicine, explains Peipei Wu Wishnow, PhD, the China-born, MIT-trained researcher who developed the formula and founded Erectile pill Inc. The company provided BetterMAN for Lue’s study.

“The formula improves blood circulation … and modulates sexual desire through the central nervous system,” Wishnow tells WebMD. “It improves male sexual functioning and decreases nighttime urination — two problems many men over 40 experience.”

Exactly how it works is not well understood, but unlike Viagra — which is supposed to be taken about an hour before intercourse — the BetterMAN mix “not only improves spontaneous erectile function, but also delays ejaculation and enhances libido,” says Wishnow. BetterMAN is taken daily, with rest periods of a few days.

In the last 10 years, says Wishnow, 5,000 Chinese men have used the formula as prescribed by physicians, with 75% reported improvements in sexual functioning and urinary control. In one small study of 45 men in the U.S., 70% reported improvements in sexual functioning and urinary control after two months of regular use.

BetterMAN has been available in U.S. stores since April 1998, Wishnow tells WebMD. Thousands of men have used it since then, and “the mix has shown no side effects or known erectile dysfunction pill
with medications — a concern many people have with Viagra,” she says.

Not everyone, including Lue, is convinced that BetterMAN is the answer to men’s woes. “I believe Viagra is still the drug of choice, “says Lue, who also involved in a clinical trial of Viagra. “However, if a patient doesn’t want Viagra and asks for herbal alternatives, I will tell him about it.”

Muta M. Issa, MD, an assistant professor of urology at Emory University School of Medicine in Atlanta, compliments the study on its methodology, but tells WebMD the results are “too preliminary” to offer any advice to humans.

“The study is done with rats — different animal, different species,” he says. “It’s quite literally there to give someone an idea, if they want to investigate, take it to the next step. Whether the herbal formula is promising or not is difficult to say.”

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Nightly Viagra May Restore Normal Erections

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May 13, 2004 — When men with erectile dysfunction take Viagra every night, rather than just when the mood strikes them, they may experience a return to normal erections, say dysfunction erectile pill
at a meeting of men’s health erectile dysfunction pill
.

“Nightly treatment may help promote erectile function as the result of this drugs’ beneficial effect on endothelial cells,” Frank Sommer, MD, said in a news conference. Endothelial cells line the walls of the blood vessels. Erections occur when the blood vessels in the penis dilate and fill with blood. Sommer, chief of andrology in the department of urology at the University of Cologne in Cologne, Germany, presented his findings at a meeting of the American Urological Erectile dysfunction meds
.

Normal Erections Without Erectile Dysfunction Treatment

He and his co-investigators studied 76 men who had erectile dysfunction for at least six months. Group 1 took 50 mg of Viagra nightly at bedtime. Group 2 took 50-100 mg of Viagra when they wanted, presumably before sexual intercourse. The investigators also followed a third group of men with erectile dysfunction who received no treatment. The men were an average of 47 years old.

After 12 months of nightly Viagra followed by one month of no erectile dysfunction treatment, nearly 60% of men in group 1 had a return of normal erections. Less than 10% of men that took Viagra as needed had a similar return of normal erections.

At the end of a six-month period without any erectile dysfunction treatment, all but one of the men in group 1 still had normal erections. Normal erections were determined by an erectile function questionnaire completed by the men.

Researchers also measured blood flow to the penis. After one month of no erectile dysfunction treatment, group 1 had a significant cialis mail order
in blood flow. However, group 2 had no significant change and blood flow, and group 3 worsened.

“This is the only study we know of that has investigated the long-term effects of taking erection-promoting therapy on a daily basis,” Sommer says. “After only one year, Viagra taken regularly at bedtime may be … a useful tool for curing erectile dysfunction.”

“This data should encourage researchers to explore this issue further,” John P. Mulhall, MD, tells WebMD.

“Erections are good for your penis, and probably good for mental health. Taking medication for erections may also be good for a man’s overall health. This is the first study to look at long-term treatment to improve erectile function in men, but the sample is too small to definitively answer the question. We really need a big study with a long follow-up to know the answers.” Mulhall, who was not involved in the study, is an associate professor and director of sexual medicine in the departments of urology at Weill Medical College of Cornell University and Memorial Sloan-Kettering Cancer Center in New York.

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Viagra Useful for Impotence Following Prostate Surgery

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Nov. 30, 1999 (Washington) — Men with prostate cancer who have their
prostate removed are usually free of cancer, but the procedure often comes with
a cost — impotence. A new study, however, shows that Viagra (sildenafil), the
popular medication for erectile dysfunction, can restore impotency lost in
surgery. Whether men respond, however, depends on how much nerve damage
occurred during surgery.

Each year some 200,000 men are diagnosed with prostate cancer and, of those,
50,000 will have to undergo surgical removal of the prostate.

Erectile dysfunction tablets
and impotence are the two most common prostatectomy side
effects. A large number of patients, even with viagra tablet
techniques, end up
with erectile dysfunction,” Milton Lakin, MD, who leads the medical urology
section at Cleveland Clinic Foundation, tells WebMD. “The first thing
doctors want to do is a very good cancer operation. Cancers are being
discovered early enough that in many cases it is possible to spare both nerves,
or at least one.”

The new study, which appears in the November Journal of Urology, was
completed by physicians at Baylor College of Medicine in Houston. It involved
about 80 men who ranged in age from 47 to 76 years old. All were prescribed
Viagra following prostate removal surgery. Based on their responses to a series
of questionnaires, 53% had improved erections and 40% had improved ability to
have intercourse.

Among those with nerves spared on both sides of the prostate, almost 60% had
improved erections and about 45% reported improvement in their ability to have
intercourse. Of men who had nerves spared on one side of the prostate, close to
40% had improvement of their ability to have intercourse. For men with no
nerves spared, the reported increase in erections dropped to 20%, with only 10%
noting an improvement in the ability to have intercourse.

At least one side effect each was experienced by 63% of the men, most
commonly flushing, headache, nasal congestion, and heartburn.

Brian Miles, MD, one of the study authors, called the results
“gratifying” and noted that the findings indicate patients should start
on the medication about six months after surgery. He tells WebMD that he has
had success with nerve transfers that involve implanting a leg nerve in the
pelvis, which can help maintain normal erectile function.

These findings confirm previous study results and put a greater spotlight on
the prostate surgery itself, says Lakin, who was not involved in this study but
has been part of nearly identical studies that produced similar results. “I
am not a surgeon. I deal primarily with sexual dysfunction. But where I think
this study will have the most impact is in causing physicians to pay more
attention to nerve sparing,” he says.

Lakin says that he commonly phentermine post soft viagra xanax
Viagra following surgery for prostate
cancer because other options are more invasive. “Erectile dysfunction treatment
, it’s very
hard not to offer a patient a pill even if their nerves have been cut, but I am
very honest with them. And if they call and say it didn’t work, we go on from
there.”

If Viagra fails, physicians can recommend other options, including
injections and vacuum devices, both of which have good success rates, even
among men whose nerves were damaged, according to Lakin.

Vital Information:

  • Viagra is an effective treatment for impotency in men who have their
    prostate removed.
  • For men whose nerves have been spared, the drug improves the ability to
    have an erection by nearly 60%, but the erectile dysfunction drugs
    drops to 20% in those
    with no nerves spared.
  • There are other options for men who don’t respond to Viagra, including
    injections and vacuum devices.

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A Cat Can Order Viagra?

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May 1, 2000 (Washington, D.C.) — Pietr Hitzig, MD, never listened to Alvin Chernov’s heart. In fact, he never even met him, let alone checked his blood pressure or pulse. Yet in March 1997, via his Internet web site, the Maryland physician diagnosed the 25-year-old Arizona man with stress-related depression and prescribed two powerful muscle relaxants for him, as well as the diet drug generic viagra pay with online check widely known as fen-phen.

Chernov received none of the careful monitoring routinely advised for patients on these drugs and, over the ensuing months, developed a pattern of behavior so bizarre that family members complained to both Hitzig and the Arizona Board of Medical Examiners. Six months later, Chernov committed suicide with a handgun. Family members attribute his death to the wild mood swings brought on by the drugs.

Last July, Hitzig, 56, was indicted on 34 federal charges of prescribing medicine illegally between 1996 and 1998. His indictment was just one skirmish in what many law enforcement officials say could become an all-out war on drug-peddling web sites. While some sites distribute drugs both ethically and legally, the vast majority of the estimated 400 online pharmacies are mailing prescription drugs, like Viagra (for impotence) and Propecia (for hair loss), to anyone with a credit card who is willing to fill out a simple questionnaire.

Medical experts complain that such practices expose patients to doses of drugs that, depending on their personal medical histories, could be lethal or cause them to become extremely ill.

Regulators point to the case of Robert McCutcheon, a 52-year-old Illinois man who had a family history of heart problems. Without seeking the counsel of his doctor, he ordered Viagra over the Internet. In March of last year, after drinking a few beers on the way home from work, he went to his girlfriend’s house, popped a Viagra, and died of a heart attack while having sex.

Merck vigorously warns expectant mothers not to even handle its Propecia pills for fear of birth defects. But Lisa Meiners, an assistant attorney general in Missouri, was able to order the drug — in a sting operation — from a Texas online pharmacy despite being 26 weeks pregnant at the time. Missouri later barred the pharmacy from doing business within its borders.

Online buyers might also find themselves obtaining defective, drug dysfunction erectile
dangerous drugs. “Americans can, unwittingly, order prescription drugs from rogue web sites that appear to be Compare generic viagra prices
companies, but are actually overseas sites offering drugs that are unapproved, buy online soft tab viagra
, insurance online viagra
, expired, mislabeled, manufactured in unapproved facilities, or not stored or handled in a proper manner,” says Sen. James Jeffords (R-Vt.), the chairman of the U.S. Senate Committee on Health, Education, and Labor.

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Competition for Viagra?

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Jan. 2, 2001 — There’s no doubt about it: Viagra is one of the most popular and best-selling drugs ever to hit the pharmacy. Since it first appeared on the market in 1998, more than 20 million prescriptions have been written for it. But while countless men have bade farewell to impotence or erectile dysfunction, others have found that Viagra does not work well for them. For these men, good news may be on the way, as researchers have discovered yet another promising treatment for sexual dysfunction.

“Many different types of treatments exist for men with erectile generic lowest price viagra
,” says Craig Dysfunction erectile pill
, MD, FACS, who explains that much of Viagra’s popularity is credited to the fact that it can be taken as a pill.

Other treatments, he adds, are less convenient and may involve injection of medication directly into the penis. Niederberger, who was not involved in the recent research, is chief of the division of andrology at the University of Illinois, in Chicago.

Dysfunction pills
, treatments for erectile dysfunction have focused on the processes that turn on smooth muscle relaxation and produce erection, rather than by blocking the contraction of smooth muscle,” says study author Christopher J. Wingard, MS, PhD. In their study, which appears in the January issue of Nature Medicine, Wingard and his colleagues looked at the latter process.

When men are sexually aroused, blood flow into the penis increases, filling up spongy cylinders called corpora cavernosa. When the cylinders fill with blood, the penis hardens and becomes erect. Acting like flood gates, muscular blood vessels called arterioles control the flow of blood into the penis. A chemical called nitric oxide is a signal for the gates to open, and Viagra works by increasing the amount of nitric oxide, signaling the gates to open and increasing the blood flow.

Researchers from the Medical College of Georgia, in Augusta decided to explore a different approach. They found that an enzyme called Rho-kinase is present in the spongy cylinders. Elsewhere, this enzyme enhances the activity of muscle, like the muscle in those flood gate muscular vessels. The researchers reasoned that if they inhibited the activity of this enzyme, the muscle would relax, opening the flood gates.

Sure enough, it worked. They injected a drug called Y-27632, a known inhibitor of Rho-kinase, into the spongy cylinders of rats, causing penile erections. In further testing, they showed that the Rho-kinase inhibition worked completely over the counter erectile dysfunction drug
of the way Viagra works.

It’s estimated that about half of all American men between the ages of 40 and 70 are affected with impotence to some degree, and the underlying causes vary. Sometimes, erectile pill
reasons or lifestyle factors, such as excessive alcohol consumption, can lead to impotence. However, a persistent problem is usually due to a chronic illness or a side effect of certain drugs.

“Viagra has proven effective in 60-70% of the general population and only about 40% effective in specific groups like diabetics who have some form of erectile dysfunction,” says Wingard. “Thus, it appears that we have a new angle on developing a therapeutic treatment of erectile dysfunction that does not rely on the action of the nitric oxide pathway.”

“The type of drug studied in this article uses an entirely new pathway to cause erections in animals, and opens the door to many new possible drugs,” says Niederberger. “If the studied drug is used in the future, it may add to the list of drugs used in direct injection.”

So, while the need exists for a wider range of therapies, and the news of this research is encouraging, it is still too early to tell whether Y-27632 will sit beside Viagra on the shelves of the local pharmacy.

While this work examined an injectable form of Y-27632, says Wingard, current research efforts have been focusing on using it in a topical form. If this method proves a viable means of administering the compound, he says, “It could lead the way for the development of a new drug treatment of erectile dysfunction.”

The study was supported by grants from the National Institutes of Health, the American Heart Association, and the American Health Assistance Foundation.

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